Pyroptosis is the "primary mechanism" behind the destruction of nerve-insulating myelin that occurs in multiple sclerosis (MS).

In contrast to traditional measures, such as an increase or worsening of lesions or overall brain atrophy, to signal progression of multiple sclerosis (MS), investigators are proposing atrophied lesion volume as a new biomarker for disease progression.

Various randomized-controlled clinical trials (RCTs) have investigated the neuroprotective role of minocycline in acute ischemic stroke (AIS) or acute intracerebral hemorrhage (ICH) patients.